Hemodynamic Correlates of P50 Suppression and Network Oscillations in Schizophrenia
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چکیده
Acknowledgements: This publication was supported from the research funding project MSM0021620816, Pathophysiology of Neuropsychiatric Disorders and Their Clinical Application and by grant GA UK 24207/2007 C-7242. References [1] Kirkpatrick, B., Buchanan, R.W., McKenney, P.D., Alphs, L.D., Carpenter, W.T. Jr., 1989. The Schedule for the Deficit syndrome: an instrument for research in schizophrenia. Psychiatry Res. 30, 119-123. [2] Kremláèek, J., Kuba, M., Kubová, Z., Langrová, J., 2006. Visual mismatch negativity elicited by magnocellular system activation. Vision Research 46, 485-490. [3] Light, G.A., Braff, D.L., 2005. Mismatch negativity deficits are associated with poor functioning in schizophrenia patients. Arch. Gen. Psychiatry 62, 127-36.
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Clinical Correlates and Neural Substrates of P50 Suppression Deficits in Schizophrenia
Copyright Information: All rights reserved unless otherwise indicated. Contact the author or original publisher for any necessary permissions. eScholarship is not the copyright owner for deposited works. Learn more at The present dissertation evaluated the P50 component of the event-related brain potential (ERP), an index of sensory gating measured during a paired-stimulus paradigm, as an inter...
متن کاملIncreased hemodynamic response in the hippocampus, thalamus and prefrontal cortex during abnormal sensory gating in schizophrenia.
OBJECTIVE Deficits in sensory gating are a common feature of schizophrenia. Failure of inhibitory gating mechanisms, shown by poor suppression of evoked responses to repeated auditory stimuli, has been previously studied using EEG methods. These methods yield information about the temporal characteristics of sensory gating deficits, but do not identify brain regions involved in the process. Hen...
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متن کاملReduced P50 suppression is associated with the cognitive disorganisation dimension of schizotypy.
Individuals with schizophrenia fail to demonstrate a reduction in the P50 event-related potential (ERP) to the second of two identical auditory stimuli presented in close succession. This deficit could lead to sensory overload, cognitive disintegration and perhaps some of the symptoms of schizophrenia. However, evidence linking poor P50 suppression to symptoms in patients with schizophrenia has...
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